Alkyl camptothecin compounds as potent inhibitors of human color

Details Alkyl camptothecin compounds as potent inhibitors of human color Alkyl camptothecin compounds as potent inhibitors of human color

1994-05-31

1995-03-28

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 17, 546 48, 546 89, 546121, 546288, C07D491147, C07D49122, A61K 3147, A61K 3144

Patent

active

054017475

ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase. I and show antileukemic and anti-tumor activity.

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