Alkyl avermectin derivatives

Details Alkyl avermectin derivatives Alkyl avermectin derivatives

1988-07-22

1990-03-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, 71 88, A61K 3170, C07H 1704, C07D31306

Patent

active

049066196

ABSTRACT:
There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4' and 4" positions which are prepared by the reaction of the 5, 10, 13, 23, 4' or 4" ketone compound with an organo-metallic Grignard reagent. The compounds are potent antiparasitic and anthelmintic agents in human and animal therapy and are potent pesticidical agents against agricultural pests. Compositions containing such compounds as the active agent are also disclosed.

REFERENCES:
patent: 4427663 (1984-01-01), Mrozik
patent: 4713571 (1979-11-01), Chabala et al.
patent: 4789684 (1988-12-01), Goegelman
Cram et al., Organic Chemistry, 2nd ed., 1964, p. 316.

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