Chemistry: fischer-tropsch processes; or purification or recover – Group viii metal containing catalyst utilized for the... – Iron containing catalyst
Patent
1992-06-12
1994-02-08
Ford, John M.
Chemistry: fischer-tropsch processes; or purification or recover
Group viii metal containing catalyst utilized for the...
Iron containing catalyst
514291, 514411, 540455, 540456, A61K 31395, C07D26700
Patent
active
052848779
ABSTRACT:
Alkyl and alkenyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and derivitization at C-17. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma; as hair revitalizing agents, especially in the treatment of male pattern alopecia oralopecia senilis; in the reversal of multidrug resistance of tumor cells; in treatment of inflammation of mucosa and blood vessels, gastric ulcers, vascular damage, ischemic bowel disease, inflammatory bowel disease, necrotizing entercolitis, intestinal lesions associated with thermal burns; in the treatment of cytomegalovirus infection; and in the treatment of idiopathic thrombocytopenic purpura and Basedow's disease.
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Tanaka, et al., J. Am. Chem. Soc., 1987, 109 5031-5033.
Holmes Mark A.
Organ Helen M.
Pisano Judith M.
Wyvratt Matthew J.
Caruso Charles M.
Ford John M.
Gupta Y. N.
Merck & Co. , Inc.
Thies J. Eric
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