Alkyl amino-glucopyranoside derivative and process for producing

Details Alkyl amino-glucopyranoside derivative and process for producing Alkyl amino-glucopyranoside derivative and process for producing

1975-06-20

1977-11-08

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 18, 536 53, A61K 3170, C07H 1504

Patent

active

040576841

ABSTRACT:
Certain alkyl amino-glucopyranoside are disclosed, including alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-D-glucopyranoside , alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-2-amino-2-deoxy-D-glucopyranoside , and alkyl di-N,N'-[N-(2-chloroethyl)-N-nitroso-carbamyl]-2,6-di-amino-2,6-di-deoxy-D -glucopyranoside. The alkyl amino-glucopryanoside exhibits marked antitumor activity while not having diabetogenic activity and bone marrow toxicity. The alkyl amino-glucopryanoside is further water soluble and free from antibacterial activity.

REFERENCES:
patent: 2235783 (1941-03-01), White
patent: 2355245 (1944-08-01), Schreiber et al.
patent: 3073788 (1963-01-01), Hostettler et al.
patent: 3577406 (1971-05-01), Hessler
patent: 3767640 (1973-10-01), Suami et al.

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