Alkyl amine derivatives of substituted quinoxaline 2,3-diones as

Details Alkyl amine derivatives of substituted quinoxaline 2,3-diones as Alkyl amine derivatives of substituted quinoxaline 2,3-diones as

1995-06-07

1997-08-05

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514114, 514252, 544354, 544337, 544230, 544295, C07D24144, C07D24152, C07D24154, A61K 31495

Patent

active

056543034

ABSTRACT:
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, Alzheimer's, Parkinson's, and Huntington's diseases.

REFERENCES:
patent: 3992378 (1976-11-01), St. Clair et al.
Copending USSN 08/124,770 (Sep. 1993).
Copending USSN 08/404,400 (Mar. 1995).
Kostic, S. et al. Bioorg. Med. Chem. Lett. 1, 403-406 (1991).
Raines, A. Basic Pharmacology in Medicine (Medical Surveillance Inc., West Chester), ed. by DiPalma, J.R. et al., pp. 314-315 (1994).

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