Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes hav

Details Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes hav Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes hav

1990-02-06

1993-04-13

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562405, 562426, 562432, 562465, 560 8, 560 9, 560 55, 560 64, 514532, 514570, C07C 6500

Patent

active

052024717

ABSTRACT:
Retinoid like activity is exhibited by compounds of the formula ##STR1## where R.sub.1 -R.sub.4 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl cycloalkyl, lower alkenyl, SR* or OR* where R* is lower alkyl, cycloalkyl or lower alkenyl; Y is lower alkenyl, lower alkynyl, lower cycloalkyl, lower branched chain alkyl or (CH.sub.2).sub.n where n is 0-6; and Z is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR' or a ketal derivative where R' is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons.

REFERENCES:
patent: 4739098 (1988-04-01), Chandraratna
patent: 4810804 (1989-03-01), Chandraratna

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