Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphos

Details Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphos Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphos

1988-03-10

1989-12-19

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

544 57, 544157, 544337, 546 22, 548112, 548413, 558170, 558169, C07F 965, C07F 909, A61K 31675, A61K 3166

Patent

active

048883280

ABSTRACT:
Novel alkoxycarbonylalkylalkylphospholipids and alkylaminocarbonylalkylphospholipids of the formula ##STR1## wherein A.sup.1 is a bivalent radical of the formula --C.sub.m H.sub.2m --wherein m is an integer having a value from 0 to 20, inclusive; A.sup.2 is a bivalent radical of the formula --C.sub.p H.sub.2p --wherein p is an integer having a value from 2 to 6, inclusive; X is a bivalent radial of the formula --O--or --N(R)--wherein R is selected from the group consisting of hydrogen, alkyl radicals having up to 6 carbon atoms, inclusive and phenyl radicals of the formula: ##STR2## where Z and a are as difined in the specification; Y is ##STR3## wherein R.sup.1 is an anlkyl radicals having up to 6 carbon atoms, inclusive and R.sup.2 and R.sup.3 are independently alkyl radicals having up to 6 carbon atoms, inclusive, or taken together with R.sup.1 and the nitrogen atom to which they are attached form a group of the formula ##STR4## wherein r is 0 or 1, and W is oxygen, CH.sub.2, sulfur or N(R.sup.4) wherein R.sup.4 is an alkyl radical having up to 6 carbon atoms, inclusive and aryl; and n is an integer having a value of 3 or 4; processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.

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