Alkoxy compounds for disease treatment

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C514S357000

Reexamination Certificate

active

07982071

ABSTRACT:
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

REFERENCES:
patent: 4214001 (1980-07-01), Engelherdt et al.
patent: 5049587 (1991-09-01), Okamoto et al.
patent: 6051605 (2000-04-01), Capiris et al.
patent: 6162943 (2000-12-01), Lui et al.
patent: 6713458 (2004-03-01), Yerxa et al.
patent: 2002/0058685 (2002-05-01), Hamilton
patent: 2003/0032078 (2003-02-01), Travis
patent: 2003/0186961 (2003-10-01), Hamilton et al.
patent: 2006/0069078 (2006-03-01), Rando
patent: 2006/0252107 (2006-11-01), Kubota et al.
patent: 2006/0281821 (2006-12-01), Palczewski et al.
patent: 396941 (1965-08-01), None
patent: 0525360 (1993-02-01), None
patent: 884663 (1959-11-01), None
patent: WO-95-19952 (1995-07-01), None
patent: WO-99-16783 (1999-04-01), None
patent: WO-2004-013082 (2004-02-01), None
patent: WO-2007-079593 (2007-07-01), None
Stella, Valentino J, Expert Opinion of Therapeutic Patents, Prodrugs as therapeutics, 2004 14(3): 277-280.
Wolff et al. (Burger's Medicinal Chemistry, 5th Ed., vol. 1, pp. 975-977, 1994.
Testa, Bernard, Biochemical Pharmacology, Prodrug Research: futile or fertile? 68 (2004) 2097-2106.
Ettmayer, Peter, Medicinal Chemistry, Lessons Learned from Marketed and Investigational Prodrugs, 47(10) (2004) 2394-2404.
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al. Advanced Drug Delivery Reviews 2001, 48, 3-26.
GB0818175.2 Search Report dated Jan. 12, 2009.
Golczak et al., “Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle,” PNAS 102(23):8162-8167 (2005).
Kano et al., A Synthesis of Dibenz[b,f]azecines from 1-halogenobenzy1-1H-2-benzazepines, Chem Pharm Bull 25(9):2401-2409 (1977).
Maeda et al., “Evaluation of the role of the retinol G protein-coupled receptor (RGR) in the vertebrate retina in vivo,” J. Neurochem. 85(4):944-956 (2003).
Mata et al., “Isomerization and Oxidation of Vitamin A in Cone-Dominant Retinas: A Novel Pathway for Visual-Pigment Regeneration in Daylight,” Neuron 36:69-80 (2002).
PCT/US08/011421 Search Report dated Dec. 23, 2008.
PK 1163/2008 Search Report dated Sep. 5, 2009.
Epstein, E., “Alkoxyphenyl N-Substituted Aminopropanols,” J. Am. Chem. Soc. 81(23):6207-6209 (1959).

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