Alkoxy and alkylthioalkylureido cephalosporins

Details Alkoxy and alkylthioalkylureido cephalosporins Alkoxy and alkylthioalkylureido cephalosporins

1976-04-19

1977-09-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 23, 544 26, 544 27, C07D50136

Patent

active

040496511

ABSTRACT:
Alkoxy and alkylthioalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is lower alkyl; Y is O or S; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.

REFERENCES:
patent: 3708479 (1973-01-01), Welch et al.
patent: 3925368 (1975-12-01), Cooper et al.
patent: 3948904 (1976-04-01), Patchornik et al.

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