[Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycyc

Details [Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycyc [Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycyc

1994-11-23

1995-06-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514438, 514445, 514449, 514460, 514473, 514529, 549 60, 549 79, 549299, 549417, 549476, 549510, 546269, 546342, 562467, A61K 31435, C07D40900, C07D31500, C07C 6364

Patent

active

054261112

ABSTRACT:
Compounds of formula ##STR1## Ar is selected from (a) phenyl, (b) phenyl substituted with one or more groups selected from halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl, (c) furyl, (d) furyl substituted with one or more groups selected from halogen, alkyl, and alkoxy, (e) pyridyl, (f) pyridyl substituted with one or more groups selected from halogen, alkyl, and alkoxy, (g) thienyl, and (h) thienyl substituted with one or more groups selected from halogen, alkyl, and alkoxy; L is selected from alkylene of one to three carbon atoms, alkenylene of two to three carbon atoms, and alkynylene of two to three carbon atoms, and ##STR2## wherein p is an integer of 1 to 4, inclusive, and R.sup.4 is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, halogen, haloalkyl of one to four carbon atoms, and alkoxy of one to six carbon atoms;
R.sup.1 is alkyl; R.sup.2 is hydrogen or alkyl; m is 1 or 2; Z is oxygen or CHOR.sup.3, and n is 0 or 1 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

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