Alkenyl-substituted spirocyclic sulfamides as inhibitors of...

Details Alkenyl-substituted spirocyclic sulfamides as inhibitors of... Alkenyl-substituted spirocyclic sulfamides as inhibitors of...

2008-05-13

2008-05-13

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S126000

Reexamination Certificate

active

10511507

ABSTRACT:
Compounds of formula (I) are disclosed: wherein R4is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease.

REFERENCES:
patent: 3406184 (1968-10-01), Raasch
patent: 3715362 (1973-02-01), Dominianni
patent: 5703129 (1997-12-01), Felsenstein et al.
patent: 2004/0029862 (2004-02-01), Belanger et al.
patent: 2004/0049038 (2004-03-01), Collins et al.
patent: WO 98/38156 (1998-09-01), None
patent: WO 01/70677 (2001-09-01), None
patent: WO 02/36555 (2002-05-01), None
G. M. Rishton et al., “Fenchylamine Sulfonamide Inhibitors of Amyloid Beta Peptide Production by the Gamma-Secretase Proteolytic Pathway . . . ”, J. Med. Chem., 2000, 43, 2297-2299.
J. E. Franz, et al.: Journal of Organic Chemistry, vol. 29, No. 10, Oct. 1964, pp. 2922-2927.
R. Huisgen, et al.: Chemische Berichte, vol. 98, No. 12, Dec. 1965, pp. 3992-4013.
S. Itsuno, et al.: Journal of the Chemical Society, Perkin Transactions 1, No. 10, Jul. 15, 1999 pp. 2011-2016.
M. Narisada, et al.: Journal of Medicinal Chemistry, vol. 31, No. 9, Sep. 1988, pp. 1847-1854.
K. B. Sharpless, et al.: Journal of Organic Chemistry, vol. 41, No. 1, Jan. 9, 1976, pp. 176-177.
Y. Yamaguchi, et al.: Xenobiotica, vol. 26, No. 6, Jun. 1996, pp. 613-626.
L. H. Zalkow, et al.: Journal of the American Chemical Society, vo. 86, No. 19, Oct. 5, 1964.
L. H. Zalkow, et al.: Journal of Organic Chemistry, vol. 28, No. 12, Dec. 1963, pp. 3303-3309.

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