Alkenyl and alkinylureido cephalosporins

Details Alkenyl and alkinylureido cephalosporins Alkenyl and alkinylureido cephalosporins

1977-03-10

1978-07-11

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D50136

Patent

active

041003446

ABSTRACT:
Alkenyl and alkinylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2 is lower alkenyl or alkinyl, R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## OR CERTAIN HETEROTHIO GROUPS; ARE DISCLOSED. These compounds are useful as antibacterial agents.

REFERENCES:
patent: 3687641 (1972-08-01), Holdrege
patent: 3954802 (1976-05-01), Kocsis
patent: 3956292 (1976-05-01), Cooper
patent: 3989693 (1976-11-01), Dolfini
patent: 3989697 (1976-11-01), Dolfini
patent: 4000134 (1976-12-01), Dolfini

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