Alkene intermediates for preparing 1,2-dioxetane compounds

Details Alkene intermediates for preparing 1,2-dioxetane compounds Alkene intermediates for preparing 1,2-dioxetane compounds

1997-08-12

1998-08-18

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483037, 548406, 548542, 549223, 556486, 568732, C07D20700, C07D31182, C07F 700

Patent

active

057959870

ABSTRACT:
Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R.sub.1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

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