Alkene, alkyne or cycloalkylene derivatives

Details Alkene, alkyne or cycloalkylene derivatives Alkene, alkyne or cycloalkylene derivatives

1985-02-21

1989-10-10

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544315, 544 31, 546153, 546242, 546243, 558388, 558413, 558423, 568 32, 568308, 568775, C07D47300, C07D21516

Patent

active

048733296

ABSTRACT:
A compound of the formula ##STR1## wherein X has the formula ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R.sup.1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkylsulphinyl and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R.sup.2, R.sup.3 and R.sup.4 is an electron-withdrawing substituent; wherein R.sup.5 and R.sup.6, which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R.sup.7 is alkyl or halogenoalkyl; and wherein R.sup.8 is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R.sup.8 is alkyl or alkenyl which bears one or more substituents selected from cyano, carbamoyl, amino, hydroxy, alkanoyl, alkoxy, alkylthio, alkenylthio, alkylsulphinyl, alkenylsulphinyl, alkylsulphonyl, alkenylsulphonyl, alkanoylamino, alkoxycarbonylamino, alkylsulphonamido, alkylamino, dialkylamino, dialkylsulphamoyl, aroyl, aryl, arylthio, arylsulphinyl, arylsulphonyl, heterocyclylthio, heterocyclylsulphinyl and heterocyclylsulphonyl; or wherein R.sup.8 has the formula ##STR3## wherein ring B is phenyl, naphthyl or heterocyclyl and wherein R.sup.2, R.sup.3 and R.sup.4 have any of the meanings stated above, provided that when R.sup.7 is methyl R.sup.8 is not also methyl.

REFERENCES:
patent: 3979471 (1976-09-01), Julia
patent: 4139561 (1979-02-01), Onopchenko et al.
patent: 4191775 (1980-03-01), Glen
patent: 4239776 (1980-12-01), Glen et al.
patent: 4282218 (1981-08-01), Glen et al.
patent: 4386080 (1983-05-01), Crossley et al.
patent: 4507140 (1985-03-01), Sugavanam
patent: 4532341 (1985-07-01), Holmwood et al.
M. Parameswara Reddy, G. S. Krishna Rao, "Synthesis," Oct. 1980, pp. 815-817.
Derwent Abstract of Japanese 52128429, 10/1977.
J. Morrow Steward and D. W. Woolley, Biochemistry, "Antimetabolites of Mevalonic Acid. II. Inhibition of Ergosterol Synthesis in Years", vol. 3, No. 12, Dec., 1964, pp. 1998-2004.

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