Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-29
2008-01-29
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S255050, C514S269000, C544S123000, C544S296000, C544S319000
Reexamination Certificate
active
10500485
ABSTRACT:
The invention relates to novel alkansulfonamides of structure (I), wherein R1is a lowel alzyl group and the other variables are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists in the treatment and prevention of diseases associated to the endothelin system
REFERENCES:
patent: 0743307 (1996-11-01), None
patent: 1191026 (2002-03-01), None
patent: WO98/57938 (1998-12-01), None
patent: WO0117976 (2001-03-01), None
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Rubanyi et al., Endothelins: Molecular Biology, Biochemistry, Pharmacology, Physiology, and Pathophysiology, Pharmacological Reviews, vol. 46, No. 3, pp. 325-415, 1994.
Harada, Hironori, et al., “Ethenesulfonamide and Ethanesulfonamide Derivatives, a Novel Class or Orally Active Endothelin-A Receptor Antagonists”, Bioorganic & Medicinal Chemistry, 2001, vol. 9, pp. 2955-2968.
Bolli Martin
Boss Christoph
Clozel Martine
Fischli Walter
Weller Thomas
Actelion Pharmaceuticals Ltd.
Hoxie & Associates LLC
Rao Deepak
LandOfFree
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