Alkanolamine derivatives

Details Alkanolamine derivatives Alkanolamine derivatives

1983-01-19

1985-10-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544407, C07D23712, C07D23720, A61K 31495

Patent

active

045501114

ABSTRACT:
Alkanolamine derivatives of the formula ##STR1## wherein Ar is phenyl or napthyl which is unsubstituted or which bears one or two defined substituents, or Ar is certain defined heterocyclic or bicyclic aromatic systems;
wherein R.sup.1 is halogen, cyano, trifluoromethyl or trifluoromethylthio;
wherein either R.sup.2 and R.sup.3 each is hydrogen or alkyl, or R.sup.2 is hydrogen and R.sup.3 is cycloalkyl or cycloalkyl-alkyl, or R.sup.2 and R.sup.3 are joined to form, together with the adjacent nitrogen atom, a heterocyclic group;
wherein either R.sup.4 is hydrogen and R.sup.5 is hydrogen or alkyl, or R.sup.4 is hydrogen and R.sup.5 and R.sup.6 are joined together to form alkylene, or R.sup.4, R.sup.5 and R.sup.6 are joined together to form alk-1-yl-.omega.-ylidene;
wherein either R.sup.6 and R.sup.7 each is hydrogen or alkyl, or R.sup.6 is joined to R.sup.4 or to R.sup.4 and R.sup.5 as defined above and R.sup.7 is hydrogen or alkyl, or R.sup.6 and R.sup.7 are joined together to form alkylene, or one of R.sup.6 and R.sup.7 is hydrogen or alkyl and the other of R.sup.6 and R.sup.7 is joined to A as defined below;
and wherein either A is alkylene, cycloalkylene or cycloalkylene-alkylene, or wherein A together with either R.sup.6 and its accompanying nitrogen atom, or R.sup.7 and its accompanying nitrogen atom, form pyrrolidine-diyl or piperidine-diyl;
and acid-addition salts thereof; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess .beta.-adrenergic blocking and/or diuretic activity.

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