Alkanoic acid derivatives

Details Alkanoic acid derivatives Alkanoic acid derivatives

1980-06-17

1982-12-07

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 9, 560 17, 560 55, 560 61, 562426, 562471, 562465, 2605011, 424308, 424316, C07C 6364, C07C 6976

Patent

active

043628915

ABSTRACT:
An alkanoic acid compound is disclosed of formula: ##STR1## and certain of its physiologically acceptable salts and esters. The alkanoic acid compound and its salts and esters have an unexpectedly greater anti-inflammatory activity than representative members of a broad class of compounds, phenyl alkane derivatives, known to have therapeutic properties. The alkanoic acid compound also has unexpectedly high antipyretic and analgesic activity. The compounds may be formulated in conventional manner as pharmaceutical compositions.
The compound may be prepared from 2-[4-(1-hydroxy-2-dimethylethyl)phenyl] propionic acid directly by dehydration or via an ester by dehydration in the presence of an alkanol followed by hydrolysis.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 3385887 (1968-05-01), Nicholson et al.
patent: 3397225 (1968-08-01), Fenton
patent: 3649668 (1972-03-01), Dolinski
patent: 3652608 (1972-03-01), Fenton
patent: 3729509 (1973-04-01), Schultz
patent: 3959364 (1976-05-01), Armitage et al.

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