Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-03-01
1978-01-03
Daus, Donald G.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424258, 260289K, 260576, C07D21522
Patent
active
040666514
ABSTRACT:
Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
REFERENCES:
patent: 3772301 (1973-11-01), Strandtmann
Kegasawa et al., "Chemical Abstracts," 1968, vol. 69:106,760n.
Brittain David Robert
Brown Edward Douglas
Hepworth Walter
Stacey Gilbert Joseph
Daus Donald G.
Imperial Chemical Industries Limited
Wheeler David E.
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