Alkanecarboxylic acid compounds which have benzofuranyl or benzo

Details Alkanecarboxylic acid compounds which have benzofuranyl or benzo Alkanecarboxylic acid compounds which have benzofuranyl or benzo

1978-08-04

1980-02-05

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603467, 546269, 546274, 549 58, 549 52, C07D30780

Patent

active

041872347

ABSTRACT:
Compounds of the formula ##STR1## in which Ar represents optionally substituted 1,2-phenylene, X.sub.1 represents oxygen or sulphur, R.sub.1 represents the radical of the formula ##STR2## in which Ph represents optionally substituted phenylene, X.sub.2 represents oxygen or sulphur, R.sub.3 and R.sub.4 independently of one another denote hydrogen or alkyl and R.sub.5 represents optionally etherified hydroxyl or optionally substituted amino and in which R.sub.2 denotes hydrogen, lower alkyl or the radical of the formula Ia and one of the groups R.sub.1 and R.sub.2 takes up the 2-position and the other takes up the 3-position, and salts of such compounds having salt-forming groups, e.g. ethyl 2-[4-(2-benzofuranyl)-phenoxy]-heptanoate. These compounds may be used as fibrinolytic and thrombolytic agents.

REFERENCES:
Goldenberg et al., Chimie Therapeutique, Jul.-Aug. 1973, No. 4, pp. 398-411.
LaForge, J.A.C.S., vol. 56, Jul. 1933, pp. 3040-3048.

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