Alkaloids of marine origin

Details Alkaloids of marine origin Alkaloids of marine origin

1989-03-29

1990-09-25

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 48, A61K 3144, C07D47116

Patent

active

049593706

ABSTRACT:
This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).

REFERENCES:
patent: 4868191 (1989-09-01), Komota et al.
N. M. Cooray et al, J. Org. Chem. (1988) 53:4619-4620.
G. P. Gunawardana et al, J. Am. Chem. Soc. (1988) 110:4856-4858.
J. Kobayashi et al, Tetraderon Lett. (1988) 29:1177-1180.
T. F. Molinsky et al, J. Org. Chem. (1988) 53:1340-1341.
A. Rudi et al, Tetrahedron Lett. (1988) 31:3861-3962.
S. J. Bloor et al, J. Am. Chem. Soc. (1987) 109:6134-6136.
G. Climino et al, Tetrahedron (1987) 43:4023-4330.
F. J. Schmitz et al, J. Am. Chem. Soc. (1983) 105:4835-4836.

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