Alkaloids from Mappia foetida, the use thereof and formulations

Details Alkaloids from Mappia foetida, the use thereof and formulations Alkaloids from Mappia foetida, the use thereof and formulations

1994-07-11

1996-06-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 48, 546 70, C07D49122

Patent

active

055256090

ABSTRACT:
The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in water, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to have pharmacodynamic properties but also to be insoluble in water. The particular water solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.

REFERENCES:
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5352789 (1994-10-01), Hinz
Wall et al. J. Am. Chem Soc vol. 88, pp. 3888-3891 (1966).
Wall et al. J. Med Chem vol. 29 pp. 1553-1555 (1986.
Gunasekera et al Jour. Nat. Prod (Lloydia) vol. 42 pp. 475-477 (1979.

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