Alkaloid that inhibits biosynthesis of mycotoxins and method...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S245000, C514S315000

Reexamination Certificate

active

07041678

ABSTRACT:
The present invention provides an alkaloid compound that is an inhibitor of mycotoxin biosynthesis. The alkaloid is an alkenyl piperidine amide wherein the alkenyl is a C18 alkenyl with one or more double bonds. The alkaloid inhibits transcription of the fungus genes nor-1, tri5, and ipnA. The present invention further provides a method for identifying compounds, which inhibit biosynthesis of aflatoxin inAspergillusspp. and deoxynivalenol inGibberellaspp. without inhibiting growth of the fungus in vitro.

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