Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-11-30
1996-06-11
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 14, 435 2, 530300, 530324, 530326, 530327, 530344, 530350, 530412, A61K 3804, A61K 3816, A01N 102, C07K 14435
Patent
active
055255922
ABSTRACT:
A composition is provided, comprising purified alkaline gland fluid (AGF) from the alkaline gland of a cartilaginous fish. The invention also provides a purified protein of approximately 12 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis under non-denaturing conditions, that decreases sperm motility and can be purified from the alkaline gland of a cartilaginous fish. Further provided are purified proteins that increase sperm motility and can be purified from the alkaline gland of a cartilaginous fish. Particularly, purified proteins of approximately 160 kD, approximately 32 kD and approximately 18 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) under non-denaturing conditions increase sperm motility. A method of increasing sperm motility comprising the step of contacting sperm with an amount of the present purified AGF composition or purified proteins effective to increase the motility of the sperm is also provided. A contraceptive method is also provided that comprises the step of contacting sperm with an amount of the purified approximately 12 kD protein effective to inhibit the motility of the sperm.
REFERENCES:
patent: 4267268 (1981-05-01), Nelson, Jr.
Grabowski et al., "Ion Transport & Fluid Alkalinization of the Alkaline Gland of the Atlantic Stingray" FASEB J. 6(4) A1458, Abstract 3024, 1991.
Winston and Handyside Science 260:932-936, 1993.
Yovich et al., Fertility and Sterility 53(4):715-722, 1990.
Maren et al., Comp. Biochem. Physiol. 10:1-16, 1963.
Smith, Homer W. J. Biol. Chem. 81:407-419, 1929.
Lacy Eric R.
Mathur Subbi
Degen Nancy J.
Lacy Eric R.
Warden Jill
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