Alkali metal and alkaline-earth metal salts of acetaminophen

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564215, A61K 3116, C07C23300

Patent

active

061600202

ABSTRACT:
Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen. The isolated salts may also be combined with other active ingredients.

REFERENCES:
patent: 2680097 (1954-06-01), Stewart
patent: 2852540 (1958-09-01), Young et al.
patent: 2998450 (1961-08-01), Wilbert et al.
patent: 3431293 (1969-03-01), Robertson et al.
patent: 3862226 (1975-01-01), Harfenist
patent: 3956490 (1976-05-01), Higuchi et al.
patent: 3987170 (1976-10-01), Rohrbach et al.
patent: 4552899 (1985-11-01), Sunshine et al.
patent: 4619934 (1986-10-01), Sunshine et al.
patent: 4681897 (1987-07-01), Brand
patent: 4783465 (1988-11-01), Sunshine et al.
patent: 4812446 (1989-03-01), Brand
patent: 5273759 (1993-12-01), Simmons
patent: 5360615 (1994-11-01), Yu et al.
patent: 5538959 (1996-07-01), Mauskop
patent: 5914129 (1999-06-01), Mauskop
Merck Index, 10th ed., 1983 p. 43.
Chemical Abstract 92:135418, 1980.
Chemical Abstract 125: 142293w, 1996.
Chemical Abstract 83: 193681t, vol. 83, 1975, p. 506.
Chemical Abstract 120: 182137b, vol. 120, 1994, p. 1354.
I.M. Kovach, Diss. Abstr., Int. B. 1975, 36 (2), 734-5.
Derwent Abstract 72,53946T (1972).
Chemical Abstracts, 88:74233S No. 11, (1978).
Getz, et al. J. Org. Chem. 1992, vol. 57, No. 6, pp. 1702-1706,"Mechanism of Hydrolysis of Benzamidomethyl Derivatives of Phenols and . . . ".
Derwent Abstract 74-25854V (1974).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Alkali metal and alkaline-earth metal salts of acetaminophen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkali metal and alkaline-earth metal salts of acetaminophen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkali metal and alkaline-earth metal salts of acetaminophen will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-218338

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.