Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1997-07-14
1998-11-24
Burn, Brian M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C07C21108
Patent
active
058409793
ABSTRACT:
The present invention relates to the use of a group of propargylamines of the general formula (I) ##STR1## wherein R.sup.1 is hydrogen or CH.sub.3 and R.sup.2 is (CH.sub.2).sub.n CH.sub.3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.
REFERENCES:
patent: 5169868 (1992-12-01), Yu et al.
Yoshida et al., Xenobiotica, 16(2), 129-136 (1986).
Yu et al., J. Neurochemistry, 63(5), 1820-1828 (1994).
Yu et al., N. Neurochemistry, 62(2), 697-704 (1994).
Yu et al., J. Medicinal Chemistry, 35(20), 3705-3713 (1992).
Yoles et al., Society for Neuroscience, 21, 562, Abstract 230.18 (1995).
Tatton et al., Neurology, 47(3), S171-S183 (1996).
Wu et al., J. Neural Trasm., 100, 53-61 (1995).
Tatton et al., J. Neurochemistry, 63(4), 1572-1575 (1994).
Tatton et al., J. Neuroscience Research, 30(4), 666-672 (1991).
Salo et al., J. Neuroscience Research, 31, 394-400 (1992).
Paterson et al., Society for Neuroscience, 23, Abstract 880.6 (1997).
Rideout et al., Society for Neuroscience, 23, Abstract 34.4 (1997).
Paterson et al., J. Neurochemistry, (in press) (1997).
Oh et al., J. Neuroscience Research, 38, 64-74 (1994).
Paterson et al., Neuroscience and Biobehavioral Reviews, 20, 1-6 (1996).
Mytilineou et al., J. Neurochemistry, 68(1), 434-436 (1997).
Mytilineou et al., J. Neurochemistry, 68(1), 33-39 (1997).
Knollema et al., Stroke, 26(10), 1883-1887 (1995).
Lai et al., Toxicology and Applied Pharmacology, 142, 186-191 (1997).
Grace et al., Chem. Res. Toxicol., 7, 286-290 (1994).
Finberg et al., J. Neural Transm., 48, 95-101 (1996).
Davis et al., American Society for Neurochemistry (Mar. 1995) (Abstract).
Boissier et al., Therapie, XXII, 367-373 (1967) (See English Summary on p. 373).
Berry et al., Progress in Neurobiology, 44, 141-161 (1994).
Ansari et al., J. Neuroscience, 13(9), 4042-4053 (1993).
Boulton Alan
Davis Bruce
Durden David
Dyck Lillian
Li Xinmin
Burn Brian M.
University of Saskatchewan
LandOfFree
Aliphatic propargylamines as cellular rescue agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aliphatic propargylamines as cellular rescue agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aliphatic propargylamines as cellular rescue agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1704519