Aliphatic or fatty acid esters as a solventless carrier for phar

Details Aliphatic or fatty acid esters as a solventless carrier for phar Aliphatic or fatty acid esters as a solventless carrier for phar

1991-11-07

1995-04-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424485, 424496, 424502, 424484, A61K 916

Patent

active

054056179

ABSTRACT:
A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50.degree.-100.degree. C.) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.

REFERENCES:
patent: 2011586 (1935-08-01), Miller
patent: 4151273 (1978-06-01), Riegelman et al.
patent: 4199576 (1980-04-01), Reller et al.
patent: 4460602 (1984-07-01), Buckwalter et al.
patent: 4820523 (1986-04-01), Shtohrya et al.
patent: 4948622 (1990-08-01), Kokubo et al.
patent: 5013759 (1991-05-01), Berman et al.
Gollamudi Ramachander, et al., "Effect of Salicylamide and Acetaminophen on Dextromethorphan Hydrobromide Metabolism: Possible Pharmacological Implications", pp. 761-764.

Affiliated with

Also associated with

Rating

Aliphatic or fatty acid esters as a solventless carrier for phar does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aliphatic or fatty acid esters as a solventless carrier for phar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aliphatic or fatty acid esters as a solventless carrier for phar will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1536923