Aliphatic nitrogenous five-membered ring compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S269000, C514S274000, C514S365000, C514S422000, C514S300000, C514S301000, C514S342000, C514S339000, C514S340000, C514S343000, C514S330000, C514S327000, C514S307000, C514S414000, C514S254010, C514S253010, C514S255010, C514S255050, C514S372000, C514S237200, C514S233500, C514S235800, C544S349000, C544S365000, C544S121000, C544S122000, C544S124000, C544S129000, C544S141000, C544S142000, C544S143000, C544S060000, C544S295000, C544S296000, C544S300000, C546S114000, C546S113000, C546S141000, C546S146000, C546S

Reexamination Certificate

active

06849622

ABSTRACT:
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:whereinA represents —CH2— or —S—,R1represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower alkoxy lower alkyl group,X represents —N(R3)—, —O— or —CO—, where R3represents hydrogen atom or a lower alkyl group, andR2represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted,or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.

REFERENCES:
patent: 6011155 (2000-01-01), Villhauer
patent: 6107317 (2000-08-01), Villhauer
patent: 6110949 (2000-08-01), Villhauer
patent: 6432969 (2002-08-01), Villhauer
patent: WO 9819998 (1998-05-01), None
patent: WO 0034241 (2000-06-01), None
patent: WO 0196295 (2001-12-01), None
patent: WO 02051836 (2002-07-01), None
Augustyns, K., et al., The Unique Properties of Dipeptidyl-peptidase IV (DPP IV / CD 26) and the Therapeutic Potential of DPP IV Inhibitors,Current Medicinal Chemistry,pp. 311-327 (1999).

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