Aliphatic nitrogen-containing 5-membered ring compound

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S269000, C514S274000, C514S365000, C514S422000, C514S300000, C514S301000, C514S342000, C514S339000, C548S538000, C548S529000, C548S525000, C548S526000, C544S349000, C544S365000, C544S121000, C544S124000, C546S114000, C546S146000

Reexamination Certificate

active

10872442

ABSTRACT:
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:wherein A represents —CH2— or —S—,R1represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower-alkoxy lower alkyl group,X represents —N(R3)—, —O— or —CO—, where R3represents hydrogen atom or a lower alkyl group, andR2represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted,or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.

REFERENCES:
patent: 6011155 (2000-01-01), Villhauer
patent: 6107317 (2000-08-01), Villhauer
patent: 6110949 (2000-08-01), Villhauer
patent: 6432969 (2002-08-01), Villhauer
patent: WO 98/19998 (1998-05-01), None
patent: WO 00/34241 (2000-06-01), None
patent: WO 01/96295 (2001-12-01), None
patent: WO 02/051836 (2002-07-01), None
Augustyns, K., et al., The Unique Properties of Dipeptidyl-peptidase IV (DPP IV / CD 26) and the Therapeutic Potential of DPP IV Inhibitors,Current Medicinal Chemistry, pp. 311-327 (1999).

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