Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-10-11
1990-01-16
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142352, 5142282, 514415, 514419, 514255, 514323, 514316, 514318, 514381, 514339, 544 585, 544121, 544129, 544143, 544360, 544364, 544373, 546273, 546187, 546201, 546194, 548251, 548253, 548494, 548503, 548468, C07D20922, C07D, C07D, A61K 31405
Patent
active
048943860
ABSTRACT:
This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N--CH.dbd.C<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Brown Frederick J.
Matassa Victor G.
ICI Americas Inc.
Jackson Thomas E.
Lee Mary C.
Magrab E. Brendan
Miano Rosemary M.
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