Aliphatic .beta.-keto esters

Details Aliphatic .beta.-keto esters Aliphatic .beta.-keto esters

1975-03-11

1977-06-21

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

96 89, 260483, 260559B, C07C 6974

Patent

active

040311309

ABSTRACT:
A process for the production of aliphatic .beta.-keto esters by reacting a dialkyl ketone with a dialkylcarbonate in the presence of an at least equivalent quantity of a basic condensation agent based on the dialkyl ketone at a reaction temperature of 20.degree. to 80.degree. C and the reaction product is subsequently converted by acidification into the .beta.-keto ester. By carrying out the condensation reaction in the presence of hexamethylphosphoric acid triamide as solvent advantageously higher yields of 20 to 50 % can be obtained by the inventive process of compared to conventional processes.

REFERENCES:
fieser et al., Reagents for Organic Synthesis, vol. 3, 149-150, (1970).
House, Modern Synthetic Reaction, 744-754, (1972).
Normant, Angew. Chem. Int. 6, 1056, 1061, (1967).
Krapcho et al., Org. Synthesis, 47, 20 (1967).

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