Alicyclic peptidomimetics

Details Alicyclic peptidomimetics Alicyclic peptidomimetics

1996-08-26

1998-10-06

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

544224, 544238, 544242, 544336, 544359, 544405, 546249, 5462681, 5483351, 5483411, 548469, 548470, 548515, 514659, 514763, 514715, 514716, 514724, 514727, 514729, 514738, C07C 3516, C07D20912, C07D21306, C07D40108

Patent

active

058178791

ABSTRACT:
Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.

REFERENCES:
patent: 5550251 (1996-08-01), Hirschmann et al.
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Raynor et al., "Analogs of Somatostatin Selectively Label Distinct Subtypes of Somatostatin Receptors in Rat Brain", J. of Pharm. And Experimental Therapeutics, 1989, 251, 510-517.
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Sherman et al., "Compatibility of Thioamides with Reverse Turn Features: Synthesis and Conformational Analysis of Two Model Cyclic Pseudopeptides Containing Thioamides as Backbone Modifications", J. Am. Chem. Soc., 1990, 112, 433-441.
Thorsett et al., "Dipeptide Mimics. Conformationally Restricted Inhibitors of Angiotensin-Converting Enzyme", Biochem. Biophys. Res. Comm., 1983, 111, 166-171.
Veber et al., "Conformationally Restricted Bicyclic Analogs of Somatostatin", Proc. Natl. Acad. Sci. USA, 1978, 75, 2636-2640.
Veber et al., "A Super Active Cyclic Hexapeptide Analog of Somatostatin", Life Sciences, 1984, 34, 1371-1378.
Veber et al., "A Potent Cyclic Hexapeptide Analogue of Somatostatin", Nature, 1981, 292, 55-58.

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