Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2005-03-08
2005-03-08
Brusca, John S. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S027000, C530S300000
Reexamination Certificate
active
06865492
ABSTRACT:
Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target. Methods are also provided for synthesizing retro-inverso peptides to the mode-matched peptide.
REFERENCES:
Mandell, A.J. (1984) Non-equilibrium behavior of some brain enzyme and receptor systems. Ann. Rev. Pharm. Toxicol. 24:237-274.
Mandell, A.J., Russo, P.V. and Blomgren, B. W. (1987) Complex hydrophobic sequence transformation predicts mutual recognition by polypeptides and proteins. Ann. N.Y. Acad. Sci. 504:88-118.
Mandell, A.J., Selz, K.A. and Shlesinger, M.F. (1997) Mode matches and their locations in the hydrophobic free energy sequences of peptide ligands and their receptor eigenfunctions. Proc. Natl. Acad. Sci. 94:13576-13581.
Mandell, A.J., Selz, K.A. and Shlesinger, M.F. (1997) Wavelet transformation of protein hydrophobicity sequences suggests their memberships in structural families. Physica A224:254-262.
Mandell, A.J., Selz., K.A. and Shlesinger, M.F. (1997) Hydrophobic free energy eigenfunctions help define continuous wavelet transformations of amino acid sequences of protein families. Proc. Intl. (Fermi) Sch. Phys. CXXXIV. 175-192.
Di Marzo, E.A. and Mandell, A.J. (1997) Phase transition behavior of a linear macromolecule threading a membrane. J. Chem. Physics 197:5510-5514.
Mandell, A.J., Owens, M.J. Selz, K.A., Morgan, W.N., Schlesinger, M.F. and Nemeroff, C.G. (1998) Mode matches in hydrophobic free energy eigenfunctions predict protein-protein interactions. Biopolymers 46:89-101.
Selz. K.A., Mandell, A.J., and Shlesinger, M.F. (1998) Hydrophobic free energy eigenfunctions of pore, channel and transporter proteins contain B-burst patterns. Biophysical J. 7:2332-2342.
Mandell, A.J., Selz, K.A. and Shlesinger, M.F. (1998) Transformational homologics in amino acid sequences suggest membership in protein families. J. Stat. Phys. 93:673-697.
Mandell, A.J., Selz., K.A., Shlesinger, M.F., and Kuhar, M.J. (1999) Linear and entropic transformations of the hydrophobic free energy sequence help characterize a novel brain polyprotein: CART. In (M.T. Batchelor and L. Wille, eds.),Statistical Physics on the Eve of the Twenty-First Century. World Scientific, NJ, pp. 131-152.
White, Stephen H. and Jacobs, Russell E. (1978) Statistical distribution of hydrophobic residues along the length of protein chains, Biophys. J., vol. 57 pp. 911-921.
Doyle, P.M. (1995) Combinatorial Chemistry in the Discovery and Development of Drugs. J. Chem. Tech. Biotechnol. 64:317-324.
Gordon, E.M., Barrett, R. W., Dower, W.J., Fodor, S.P.A. and Gallop, M.A. (1994) Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions. J. Med. Chem. 37(10):1385-1401.
Houghton. R.A. (1993) The Broad Utility of Soluble Peptide Libraries for Drug Discovery. Gene 137:7-11.
Mandell, Arnold J., Selz, Karen A., and Shlesinger, Michael F. Predicting Peptide Receptor Peptide- Protein, and Chaperone-Protein Binding using patterns in amino acid hydrophobic free energy sequences, The Journal of Physical Chemistry B, vol. 104, No. 16, pp. 3953-3959.
Mandell Arnold J.
Selz Karen A.
Shlesinger Michael F.
Brusca John S.
Halluin Albert P.
Howrey Simon Arnold and White
The Cielo Institute, Inc.
LandOfFree
Algorithmic design of peptides for binding and/or modulation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Algorithmic design of peptides for binding and/or modulation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Algorithmic design of peptides for binding and/or modulation... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3374321