Alginate-based vaccine compositions

Details Alginate-based vaccine compositions Alginate-based vaccine compositions

1995-02-27

1997-10-07

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4242781, 4242341, 4242801, 4242811, 424424, 424434, 424438, 424480, 424492, A61K 3900, A61K 4500, A61K 3902, A61F 1300

Patent

active

056744951

ABSTRACT:
A vaccine composition including an antigen dispersed in an alginate gel is described. The alginate gel is preferably in the form of discrete particles coated with a polymer. Vaccination of vertebrate species can be accomplished by administering the alginate-based vaccine compositions orally.

REFERENCES:
patent: 4220152 (1980-09-01), Dresback
patent: 4391909 (1983-07-01), Lim
patent: 4798786 (1989-01-01), Tice et al.
patent: 5352448 (1994-10-01), Bowersock et al.
Cohen et al. 1991. Proce. Natl. Acad. Sci. USA vol. 88: 10440-10444.
Offit et al. 1994. Virology, 203:134-143. "Enhancement of Rotavirus Immunogenicity by Micro.".
An influence of the structure of alginate on the chemotactic activity of macrophages and the antitumor activity. Michio Fujihara et al. Carbohydrate Research, 243, 211-216, 1993.
In vitro activation of human macrophages by alginate-polylysine microcapsules. Maria E. Pueyo et al. J. Biomater. Sci. Polymer Edn, vol. 5, No. 3, pp. 197-203, 1993.
Calcium Alginate Hydrogel as Matrix for Enteric Delivery of Nucleic Acids. Timothy J. Smith. Pharmaceutical Technology, pp. 26-30, Apr., 1994.
Long-term reversal of diabetes by injection of immunoprotected islets. Patrick Soon-Shiong et al. Proc. Natl. Acad. Sci. USA, vol. 90, pp. 5843-5847, Jun., 1993.
An Immunologic Basis for the Fibrotic Reaction to Implanted Microcapsules. P. Soon-Shiong et al. Transplantation Proceedings, vol. 23, No. 1, pp. 758-759, 1991.
Induction of Pulmonary Antibodies to Pasteurella haemolytic Following Intraduodenal Stimulation of the Gut-assocaited Lymphatic Tissue in Cattle. Terry L. Bowersock et al. Can J Vet Res, vol. 53, pp. 371-377, 1989.
Controlled Vaccine Release in the Gut-Associated Lymphoid Tissues. I. Orally Administered Biodegradable Microspheres Target the Peyer's Patches. John H. Eldridge et al. Journal of Controlled Release, vol. 11, pp. 205-214, 1990.
The Common Mucosal Immune System and Current Strategies for Induction of Immune Responses in External Secretions. Jiri Mestecky. Journal of Clinical Immunology, vol. 7, No. 4, 1987.
Recent Progress in Protein and Peptide Delivery by Noninvasive Routes. Lorraine L. Wearley, Critical Reviews in Therapeutic Drug Carrier Systems, vol. 8, pp. 331-394, 1991.
Liposomes Containing Anti-Idiotypic Antibodies: an Oral Vaccine To Induce Protective Secretory Immune Responses Specific for Pathogens of Mucosal Surfaces. Susan Jackson et al. Infection and Immunity, vol. 58, No. 6, pp. 1932-1936, 1990.
Stimulation of Immunity to Pasteurella Multocida in Rabbits by Oral Immunization using a Microsphere Delivery System. M.A. Suckow et al. Proceed. Intern. Symp. Control. Ref. Bioact. Mater. vol. 21, 1994.
Uptake of Alginate Microspheres by Peyer's Patches. T.L. Bowersock et al. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. vol. 21, 1994.
Oral Administration of Mice with Ovalbumin Encapsulated in Alginate Microspheres. T.L. Bowersock et al. Journal: Abstracts of Papers of the American Chemical Society, vol. 208, Aug. 1994.
Diabetic Dogs Thrive with Islet Transplants. David N. Leff. BioWorld Today. vol. 4, No. 11, pp. 1 and 4, 1993.
Induction of Cytokine Production from Human Monocytes Stimulated with Alginate. Marit Otterlei et al. Journal of Immunotherapy, vol. 10, pp. 286-291, 1991.
Living Cure. Philip E. Ross. Scientific American, pp. 18-23, Jun. 1993.
Controlled release of water-soluble macromolecules from bioerodible hydrogels. J. Heller et al. Biomaterials, vol. 4, No. 4, pp. 262-266, Oct. 1983.
Biodegradable microparticles for oral immunization. O'Hagan et a. Vaccine;vol. 11, pp. 149-152, 1993.
Protective effects of an oral microencapsulated Mycoplasma hyopneumoniae vaccine against experimental infection in pigs. Weng et al. Res Vet Sci, vol. 53, pp. 42-46, 1992.

Affiliated with

Also associated with

Rating

Alginate-based vaccine compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alginate-based vaccine compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alginate-based vaccine compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2354513