Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1987-07-28
1989-09-12
Ford, John M.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514383, 548269, C07C24908, A61K 3141
Patent
active
048658375
ABSTRACT:
A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.
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Mario Grifantini et al, "Structure-Activity Relationships in Reactivators of Organophosphorus-Inhibited Acetylcholinesterase V: Quaternary Salts of Hydroxyiminomethylimidazoles", Journal of Pharmaceutical Sciences, vol. 61, No. 4, Apr. 1972, pp. 631-633.
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Bedford Clifford D.
Harris, III Ralph N.
Hilmas Duane E.
Howd Robert A.
Kenley Richard A.
Ford John M.
SRI - International
Taylor John P.
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