Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-04-19
1990-05-15
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514101, 514397, 514400, 546278, 548336, 548343, A61K 3144, C07D40106
Patent
active
049258567
ABSTRACT:
A therapeutically effective class of low toxicity aldoxime-substituted functionalized imidazolium compounds and compositions is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these aldoxime-substituted imidazolium derivatives has been found to save mammals having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.
REFERENCES:
Chemical Abstracts, 102:1630s(1985) [A. Miller, et al., Proc. West. Pharmacol. Soc. 1984, 27, 297-301].
Chemical Abstracts, 75:98534y (1971) [E. Glover, et al., J. Chem. Soc. c 1971, (16), 2748-9].
C. Bedford, et al., J. Med. Chem. 1984, 27, 1431.
Bedford Clifford D.
Goff Dane A.
Harris, III Ralph N.
Hilmas Duane E.
Howd Robert A.
Schwartz Richard A.
SRI - International
Taylor John P.
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