Aldosterone-antagonistic steroids

Details Aldosterone-antagonistic steroids Aldosterone-antagonistic steroids

1984-01-05

1985-03-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, C07J 100

Patent

active

045029890

ABSTRACT:
Novel spironolactone derivatives characterized by the C.sub.11 -C.sub.12 double bond which have a potent aldosterone-antagonistic activity without causing potassium loss, used alone in diagnosis and improvement of condition of primary aldosteronism, or together with other drugs in treatment of essential or renal hypertension as well as cardiac or renal edema; prepared from 3,17-bis(ethylene-dioxy)-5,11-androstadiene.

REFERENCES:
patent: 4129564 (1978-12-01), Wiechert et al.

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