Aldose reductase inhibitor

Details Aldose reductase inhibitor Aldose reductase inhibitor

1991-08-08

1992-10-13

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5940, A01N 3710

Patent

active

051552590

ABSTRACT:
An aldose reductase inhibitor, comprising a compound of the formula (I) ##STR1## or a pharmaceutically acceptable salt thereof as the effective component, in which R is lower alkyl or cyclohexylmethyl and n is 2 or 3. The compounds of formula (I) and salts thereof according to the invention exhibit a superior aldose reductase inhibiting activity with simultaneous high stability, so that they are useful for the prevention and therapy of diabetic complications.

REFERENCES:
Node, M. et al., J. Org. Chem. 46(10) 1991-3, 1981.
Luedemann, H., Macromol. Chem. 175(8) 2393-407, 1974.
Pachaly, Peter, Arch. Pharm. 322(8) 483-7, 1989.
Chaudhury, H. et al., J. Chem. Soc. C16, 2070-7, 1969.

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