Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-02-09
1994-02-08
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435126, 549456, 549458, A61, C07D30792, C07D30777, C12P 1704
Patent
active
052848701
ABSTRACT:
The present invention relates to an aldose reductase inhibitor represented by the formula: ##STR1## wherein R.sub.1 is (CH.sub.2).sub.2 COOH and R.sub.2 is phenyl or p-hydroxyphenyl, or R.sub.1 and R.sub.2 are combined together to form a group of the formula: ##STR2## which was isolated from the fermentation products of Chaetomella circinoseta RF-3192.
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Derwent Publication Ltd., AN-89-036772/05, JP-A-63-310835 (1988).
Derwent Publication Ltd., AN-88-238170/34, JP-A-63-170392 (188).
J. Chem. Soc. Perkin. Trans. I., H. Arzeno, et al., pp. 2069-2076, 1984.
Chemical Abstracts, vol. 107, AN-115302y, M. V. Bhatt, et al. (1987).
Synthesis, pp. 713-716, Jun. 4, 1977, S. H. Ruetman.
Metabolism, vol. 34, No. 10, Oct. 1985, pp. 885-892, N. Simard-Duquesne, et al.
Derwent Publication Ltd., AN-88-231647/33, JP-A-63-165323 (1988).
Itazaki Hiroshi
Kato Toshiyuki
Kawamura Yoshimi
Matsumoto Koichi
Yoshida Tadashi
Dentz Bernard
Shionogi Seiyaku Kabushiki Kaisha
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