Aldose reductase inhibition by 5-fluoro-2-methyl-1-[[4-(methylth

Details Aldose reductase inhibition by 5-fluoro-2-methyl-1-[[4-(methylth Aldose reductase inhibition by 5-fluoro-2-methyl-1-[[4-(methylth

1981-12-21

1983-12-27

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3119

Patent

active

044230745

ABSTRACT:
Disclosed are new methods of using 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid or a therapeutically acceptable salt thereof with an organic or inorganic base for the treatment of complications associated with diabetes mellitus. The compound inhibits lens aldose reductase in a diabetic mammal.

REFERENCES:
patent: 3647858 (1972-03-01), Hinkley et al.
patent: 3654349 (1972-04-01), Shen et al.
patent: 3821383 (1974-06-01), Sestanj et al.
"Physicians Desk Reference", 34th Ed. Medical Economics Co., Oradell, N.J., pp. 1147-1149.
J. R. Ryan et al., Clin. Pharmacol. Ther., 21, 231, (1977).
D. E. Duggan et al., Biochem. Pharm., 27, 2311, (1978).

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