Aldose reductase inhibition by 1-methyl-5-(4-methylbenzoyl)-1H-p

Details Aldose reductase inhibition by 1-methyl-5-(4-methylbenzoyl)-1H-p Aldose reductase inhibition by 1-methyl-5-(4-methylbenzoyl)-1H-p

1981-08-17

1983-12-27

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

A61K 3140

Patent

active

044230605

ABSTRACT:
Disclosed are new methods of using 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid or a therapeutically acceptable salt thereof with an organic or inorganic base for the treatment of complications associated with diabetes mellitus. The compound inhibits lens aldose reductase in a diabetic mammal.

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patent: 4370340 (1983-01-01), Ueda et al.
D. Dvornik et al., Science, 182, 1146 (1973).
Chem. Abst. vol. 88 (1978) 506m and 146127k.
J. Carsen et al., J. Med. Chem. 14 646 (1971).
Physician's Desk Reference 34 Ed. (1980) pp. 1104-1106.
Chlud et al., Int. J. Clin. Pharmacology 15, 409 (1977).

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