Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-m

Details Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-m Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-m

1981-07-23

1984-04-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

A61K 3140

Patent

active

044421184

ABSTRACT:
Disclosed are new methods of using 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, or a therapeutically acceptable salt thereof with an organic or inorganic base for the treatment of complications associated with diabetes mellitus. The compound inhibits lens aldose reductase in a diabetic mammal.

REFERENCES:
Chemical Abstracts 91: 49605u (1979).
Chaudbury et al., J. Diab. Ass. India, 16/2, pp. 59-64 (1976).
Schlumpf, Schiveiz Med. Wochenscher 108/1, pp. 28-34 (1978).
Widstron, Horm, Metab. Res. 9/3, pp. 172-175 (1977).

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