Aldehydic agents for allosteric modification of hemoglobin

Details Aldehydic agents for allosteric modification of hemoglobin Aldehydic agents for allosteric modification of hemoglobin

1994-09-19

1997-02-04

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 85, 560 86, 560130, 560143, C07C 5142

Patent

active

055999743

ABSTRACT:
Chemical compounds which interact inside the central water cavity of hemoglobin and bridge between the two .alpha. subunits can be used to allosterically modify hemoglobin towards tense and relaxed states. The functional groups employed are aldehydes and carboxylic acids, wherein the aldehydes form covalent bonds (schiff base) with amino acid residues of hemoglobin and the carboxylic acids form ionic bonds with amino acid residues of hemoglobin. Particularly useful compounds within the practice of this invention bond to the n-terminal valine of one .alpha. subunit of hemoglobin, and the lysine 99 and/or arginine 141 of the other .alpha. subunit.

REFERENCES:
CA 111:97589 (1989).
CA 118: 82355 (1992).
CA 116: 54888 (1991.
CA 119: 27840 (1993).

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