Aldehyde tags, uses thereof in site-specific protein...

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Reexamination Certificate

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C536S023100

Reexamination Certificate

active

07985783

ABSTRACT:
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.

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