Aldehyde oxidase inhibitors for treatment of aids

Details Aldehyde oxidase inhibitors for treatment of aids Aldehyde oxidase inhibitors for treatment of aids

1997-12-01

2000-03-21

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424468, 435 25, 435184, 435191, 435163, 514 50, 514 51, 514974, A61K 3170, A61K 900, A61K 922

Patent

active

060404345

ABSTRACT:
A new pathway of metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine (AMT) has been described. This pathway involves the enzyme aldehyde oxidase. Aldehyde oxidase inhibitors may be used to reduce AMT formation during therapy with AZT.

REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4833130 (1989-05-01), Rideout et al.
patent: 5234913 (1993-08-01), Furman, Jr, et al.
Beedham, Christine; "Molybdenum Hydroxylases as Drug-Metabolizing Enzymes", Metabolism Reviews, 16 (1&2): 119-156; 1986.
Cretton, Erika M., et al.; "Catabolism of 3'-Azido-3'-deoxythymidine in Hepatocytes and Liver Microsomes, with Evidence of Formation of 3'-Amino-3'-deoxythymidine, a Highly Toxic Catabolite for Human Bone Marrow Cells"; Molecular Pharm., 39: 258-266; 1991.
Eagling, V.A., et al.; "The Metabolism of Zidovudine by Human Liver Microsomes In Vitro: Formation of 3'-Amino-3'-deoxythymidine", Biochem. Pharmacol.; 48(2): 267-276; 1994.
Fitzsimmons, Michael E., et al.; "Selective Biotransformation of the Human Immunodeficieny Virus Protease Inhibitor Saquinavir by Human Small-Intestinal Cytochrome P4503A4"; Drug Metab. and Disp.; 25: 256-266; 1997.
Kitamura, Shigeyuki, et al.; "Reduction of Tertiary Amine N-Oxides by Liver Preparations: Function of Aldehyde Oxidase as a Major N-Oxide Redctase"; Biochemical and Biophysical Research Comms.; 121 (3): 749-754; 1984.
Kumar, Gondi N., et al.; "Cytochrome P450--Mediated Metabolism of the HIV-1 Protease Inhibitor Ritonavir (ABT-538) in Human Liver Microsomes"; J. Pharmacol. Exp. Ther.; 277: 423-431; 1996.
McLeod, Gavin X., et al.; "Zidovudine: Five Years Later"; Annals of Internal Medicine, 117: 487-501; 1992.
Stagg, M. Patrick, et al.; "Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine"; Clin. Pharmacol. Ther.; 51: 668-676; 1992.
Sugihara, Kazumi, et al.; "Involvement of Mammalian Liver Cytosols and Aldehyde Oxidase in Reductive Metabolism of Zonisamide"; Drug Metab. and Disp.; 24(2): 199-202; 1996.
Veal, Gareth J., et al., "Metabolism of Zidovudine"; Gen. Pharmac.; 26(7): 1469-1475; 1995.

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