Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-12-01
2000-03-21
Wilson, James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424468, 435 25, 435184, 435191, 435163, 514 50, 514 51, 514974, A61K 3170, A61K 900, A61K 922
Patent
active
060404345
ABSTRACT:
A new pathway of metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine (AMT) has been described. This pathway involves the enzyme aldehyde oxidase. Aldehyde oxidase inhibitors may be used to reduce AMT formation during therapy with AZT.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4833130 (1989-05-01), Rideout et al.
patent: 5234913 (1993-08-01), Furman, Jr, et al.
Beedham, Christine; "Molybdenum Hydroxylases as Drug-Metabolizing Enzymes", Metabolism Reviews, 16 (1&2): 119-156; 1986.
Cretton, Erika M., et al.; "Catabolism of 3'-Azido-3'-deoxythymidine in Hepatocytes and Liver Microsomes, with Evidence of Formation of 3'-Amino-3'-deoxythymidine, a Highly Toxic Catabolite for Human Bone Marrow Cells"; Molecular Pharm., 39: 258-266; 1991.
Eagling, V.A., et al.; "The Metabolism of Zidovudine by Human Liver Microsomes In Vitro: Formation of 3'-Amino-3'-deoxythymidine", Biochem. Pharmacol.; 48(2): 267-276; 1994.
Fitzsimmons, Michael E., et al.; "Selective Biotransformation of the Human Immunodeficieny Virus Protease Inhibitor Saquinavir by Human Small-Intestinal Cytochrome P4503A4"; Drug Metab. and Disp.; 25: 256-266; 1997.
Kitamura, Shigeyuki, et al.; "Reduction of Tertiary Amine N-Oxides by Liver Preparations: Function of Aldehyde Oxidase as a Major N-Oxide Redctase"; Biochemical and Biophysical Research Comms.; 121 (3): 749-754; 1984.
Kumar, Gondi N., et al.; "Cytochrome P450--Mediated Metabolism of the HIV-1 Protease Inhibitor Ritonavir (ABT-538) in Human Liver Microsomes"; J. Pharmacol. Exp. Ther.; 277: 423-431; 1996.
McLeod, Gavin X., et al.; "Zidovudine: Five Years Later"; Annals of Internal Medicine, 117: 487-501; 1992.
Stagg, M. Patrick, et al.; "Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine"; Clin. Pharmacol. Ther.; 51: 668-676; 1992.
Sugihara, Kazumi, et al.; "Involvement of Mammalian Liver Cytosols and Aldehyde Oxidase in Reductive Metabolism of Zonisamide"; Drug Metab. and Disp.; 24(2): 199-202; 1996.
Veal, Gareth J., et al., "Metabolism of Zidovudine"; Gen. Pharmac.; 26(7): 1469-1475; 1995.
Fayz Shirin
Inaba Tadanobu
Stewart David John
Owens Howard
Wilson James O.
LandOfFree
Aldehyde oxidase inhibitors for treatment of aids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aldehyde oxidase inhibitors for treatment of aids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aldehyde oxidase inhibitors for treatment of aids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-731411