Aldehyde derivatives of prostaglandins

Details Aldehyde derivatives of prostaglandins Aldehyde derivatives of prostaglandins

1974-12-30

1976-04-27

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260598, C07C17700

Patent

active

039534359

ABSTRACT:
Prostaglandin analogues of the formula:- ##SPC1##
Wherein A represents a PGF or PGE grouping, X represents ethylene or cis-vinylene, Y represents ethylene or transvinylene, R.sup.1 represents hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 represents alkyl of 1 to 10 carbon atoms, or alkyl of 1 to 4 carbon atoms substituted by phenyl or cycloalkyl containing from 5 to 7 carbon atoms, or R.sup.2 represents a grouping of the formula:- ##SPC2##
Wherein R.sup.3 represents alkylene of 1 to 4 carbon atoms, R.sup.4 represents oxygen or sulphur or sulphinyl, and R.sup.5 and R.sup.6 represent hydrogen, halogen, trifluoromethyl, alkyl of 1 to 3 carbon atoms are new compounds possessing pharmacological properties.

REFERENCES:
patent: 3504020 (1970-03-01), Lapidus et al.
patent: 3636120 (1972-01-01), Pike
patent: 3749741 (1973-07-01), Strike et al.
patent: 3810943 (1974-05-01), Jones et al.
patent: 3849474 (1974-11-01), Nedumparambel et al.
patent: 3878239 (1975-04-01), Hayashi et al.

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