Alcohol or aldehyde derivatives and their use

Details Alcohol or aldehyde derivatives and their use Alcohol or aldehyde derivatives and their use

1995-06-27

1997-06-17

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 514394, 548496, 548510, 5483051, A61K 3140, C07D20908

Patent

active

056397810

ABSTRACT:
The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R.sup.2 and R.sup.3 independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.4 is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: --CHO or --CH.sub.2 OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R.sup.4 is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R.sup.1 is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R.sup.2 and R.sup.3 independently are a lower alkyl or arylalkyl, X is --CHO, m is 1 and n is 0 or 1, or a salt thereof.
Compound (I) is useful as a prophylactic/therapeutic agent for osteoporosis.

REFERENCES:
Driguez et al., Canadian Journal of Chemistry, vol. 56, pp. 119-130 (1978).
Towatari et al., FEBS Letters, vol. 280, No. 2, pp. 311-315 (1991).
Aoyagi et al., The Journal of Antibiotics, vol. 22, No. 6, pp. 283-286 (1969).
Hanada et al., Agricultural and Biological Chemistry, vol. 42, No. 3, pp. 523-541 (1978).
Murata et al., FEBS Letters, vol. 280, No. 2, pp. 307-310 (1991).

Affiliated with

Also associated with

Rating

Alcohol or aldehyde derivatives and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alcohol or aldehyde derivatives and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alcohol or aldehyde derivatives and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2158210