Alcohol dehydrogenase and its use for the enzymatic production o

Details Alcohol dehydrogenase and its use for the enzymatic production o Alcohol dehydrogenase and its use for the enzymatic production o

1997-03-21

2000-03-14

Sisson, Bradley

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C12N 904

Patent

active

060371587

ABSTRACT:
Stable microbial enzyme with alcohol dehydrogenase activity having an activity maximum at ca. 50.degree. C., process for its isolation and its use for the enantioselective reduction/oxidation of organic keto compounds/hydroxy compounds wherein, depending on the type of the starting compounds R- or S-hydroxy compounds are obtained. In particular an alcohol dehydrogenase obtainable from Lactobacillus brevis has proven to be suitable.

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Hummel (1990) Enzyme-catalyzed synthesis of optically pure R(+)-phenylethanol. Biotechnology Letters 12(6): 403-408, Jun. 1990.
Zheng et al. (1994) Asymmetric reduction of aliphatic and cyclic ketones with secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus: effects of substrate structure and temperature. Catalysis Today 22(3): 607-620, Dec. 1994.
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Ngo et al. (1994) Computational complexity, protein structure prediction, and the ILevinthal paradox. In: The Protein Folding Problem and Tertiary Structure Prediction. Eds. Merz et al. Birkhauser et al. Boston, MA. pp. 491-495, Jan. 1994.
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