Alcanoic acid amides substituted by saturated O-heterocycles

Details Alcanoic acid amides substituted by saturated O-heterocycles Alcanoic acid amides substituted by saturated O-heterocycles

2006-09-14

2011-11-15

Oh, Victor (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S458000, C514S459000, C546S152000, C549S023000, C549S396000, C549S426000

Reexamination Certificate

active

08058307

ABSTRACT:
Compounds of the general formula (formula I) in which the meanings of the substituents R1 to R6 are as indicated in claim1, have renin-inhibiting properties and can be used as medicines.

REFERENCES:
patent: 5627182 (1997-05-01), Göschke et al.
patent: 2006/061427 (2006-06-01), None
patent: 2006/095020 (2006-09-01), None
International Search Report issued Apr. 3, 2007 in the International (PCT) Application PCT/EP2006/066368 of which the present application is the U.S. National Stage.
Written Opinion in the International (PCT) Application PCT/EP2006/066368 of which the present application is the U.S. National Stage, Mar. 4, 2007.
Jeanette M. Wood et al., “Structure-based design of aliskiren, a novel orally effective renin inhibitor”, Biochemical and Biophysical Research Communications, Academic Press Inc., vol. 308, No. 4, pp. 698-705, XP004447169, ISSN: 0006-291X, Sep. 5, 2003.
Richard Göschke et al., “Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-Hydroxy-8-Phenyl-Octanecarboxamides as In Vitro Potent Peptidomimetic Inhibitors of Human Renin”, Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 21, pp. 2735-2740, XP004136522, ISSN: 0960-894X, Nov. 4, 1997.

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