Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Bacterium or component thereof or substance produced by said...
Patent
1980-07-10
1981-12-01
Rosen, Sam
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Bacterium or component thereof or substance produced by said...
424305, 424317, A61K 3134
Patent
active
043036716
ABSTRACT:
The present invention provides novel formulations of prostacyclin suitable for parenteral administration and methods for making and using these formulations. These novel formulations include a pharmaceutically acceptable stabilizing concentration of albumin as a constituent thereof. Such novel formulations of prostacyclin are useful for its conventional pharmacological and therapeutical purposes, most to inhibition of blood platelet aggregation.
REFERENCES:
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Borda, et al., "Human Platelet Rich Plasma and Human Serum Protects from Inactivation the Antiaggregatory Effect of Prostacyclin . . . " Prostaglandins 19:899-905 (1980).
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D. D. Pifer, et al., "Stabilization of PGI.sub.2 by Human Plasma and Human Serum Albumin", published abstract from an FASEB Meeting in Anaheim, California (Apr. 14-20, 1980).
Rao, et al., "Influence of pH on Prostacyclin Mediated Inhibition of Platelet Function", Prostaglandins and Medicine 4:263-273 (1980).
M. J. Cho, et al., "Chemical Stability of Prostacyclin (PGI.sub.2) in Aqueous Solutions", Prostaglandins 15:943-954 (1978).
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Armitage Robert A.
Hattan L. Ruth
Rosen Sam
The Upjohn Company
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