Albumin-binding conjugates comprising a fatty acid and PEG

Details Albumin-binding conjugates comprising a fatty acid and PEG Albumin-binding conjugates comprising a fatty acid and PEG

2011-03-22

2011-03-22

Carr, Deborah D (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S546000

Reexamination Certificate

active

07910618

ABSTRACT:
The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

REFERENCES:
patent: WO00/26256 (2000-05-01), None
patent: WO 02/065985 (2002-08-01), None
patent: WO02/065985 (2002-08-01), None
patent: WO03/022210 (2003-03-01), None
patent: WO 03/022210 (2003-03-01), None
patent: WO 03/049684 (2003-06-01), None
patent: WO03/049684 (2003-06-01), None
Allen T Met Al: Biochimica Et Biophysica Acta, Amsterdam, NL, vol. 1237, No. 2, Jul. 26, 1995, pp. 99-108.
Knudsen Lotte B et al: Journal of Medicinal Chemistry, American Chemical Society. Washington, US, vol. 43, No. 9, May 4, 2000, pp. 1 664-1669.
Hamilton-Wessler Met Al.: Diabetologia, vol. 42, 1999, pp. 1254-1263.
Kurtzhals, Peter et al., “Albumin Binding of Insulins Acylated with Fatty Acids: Characterization of the Ligand-Protein Interaction and Correlation Between Binding Affinity and Timing of the Insulin Effect in vivo”, Biochem. J., 1995, vol. 312, pp. 725-731.
Allen, Theresa M. et al., “A New Strategy for Attachment of Antibodies to Sterically Stabilized Liposomes Resulting in Efficient Targeting to Cancer Cells”, Biochimica et Biophysica Acta, 1995, vol. 1237, pp. 99-108.
Knudsen, Lotte B. et al., “Potent Derivatives of Glucagon-Like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration”, J. Med. Chem., 2000, vol. 43, pp. 1664-1669.
Hamilton-Wessler, M. et al., “Mechanism of Protracted Metabolic Effects of Fatty Acid Acylated Insulin, NN304, in Dogs: Retention of NN304 by Albumin”, Diabetologia, 1999, vol. 42, pp. 1254-1263.
International Search Report for PCT/GB2005/002084 dated May 9, 2006.

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